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    Breakfast included
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    Check In: 3:00 PM  |  Check Out: 11:00 AM


      120 S. Interstate Drive, Sikeston
      (Includes VAT)
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      Welcome to Holiday Inn Express Sikeston

      Hotel's Address in Sikeston, MO Near I-55

      Large, illuminating windows and contemporary decor welcome you to the Holiday Inn Express® Sikeston. Our hotel's address in Sikeston, MO surrounds you with fun attractions.

      Thanks to a convenient location near I-55 and nearby companies, business travelers are drawn to our hotel. Sikeston, MO is home to a variety of companies, including John Deere, Monsanto, Orgill, Tyson Foods and Unilever. In addition, we provide guests with a selection of handy services at our state-of-the-art business center.

      Experience the charm of Sikeston with our hotel's proximity to attractions like Lambert's Cafe, an eatery that's famous for throwing tasty rolls to customers. Sikeston is also home to the annual Sikeston Jaycee Bootheel Rodeo, which draws large crowds every August. Our accommodations are near the home venue of the Sikeston Bulls and two 18-hole golf courses, as well as the twenty or more shops at Sikeston Factory Outlet Mall.

      Whether you're staying at our hotel in Sikeston, MO for business or pleasure, we have the amenities to satisfy your needs. Connecting to colleagues and family is easy with the free high-speed, Wi-Fi access, and mornings are great with a cup of coffee and gooey cinnamon roll from our free, hot Express Start breakfast bar. Go for a dip in the indoor pool or burn calories in our state-of-the-art fitness center. If you're looking for lodging in Sikeston, our hotel's the smart choice.

      Features When it comes to hotels in Sikeston, MO, you won't find a better one. Guests constantly rave about our unbeatable free Express Start breakfast bar, clean accommodations and friendly staff and service.

      Business Services

      Wireless Data Connection
      Business Center

      Health and Fitness Center (On-site)

      Health/Fitness Center On-Site

      Entertainment and Recreation

      Indoor Pool

      Housekeeping and Laundry Services

      Daily Housekeeping

      Weekly Housekeeping

      Dry Cleaning Pickup or Laundry Valet

      Same Day Dry Cleaning


      Safety Deposit Box available at Front Desk

      Air Conditioning in Public Areas

      Ice Machine

      Guestroom data services

      Wireless Data Connection


      Business Center data services

      Wireless Data Connection


      Public space data services

      Wireless Data Connection


      • Number of parking spaces:55
      • Parking is free at out property. Large vehicles need to contact to make arrangements.
      • We are sorry, but no pets are allowed.
      • American Express
      • JCB
      • MasterCard
      • Visa
      • English


      • Number of rooms: 4
      • Parking
      • Service Animals Allowed

      Hotel areas that are accessible:

      Guest Rooms

      Exercise Facility


      Business Center

      Registration Desk

      Public Entrance

      Hotel areas with accessible routes from accessible public entrance:

      Exercise Facility


      Business Center

      Registration Desk

      Accessible Guest Rooms

      Hotel provides the following:

      TTY for Guest Use

      Communication Kits With Visual Alarms And Notification Devices

      Closed Caption Televisions

      Accessible Self Parking

      Van Accessible Self Parking