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    Check In: 3:00 PM  |  Check Out: 11:00 AM

    Cape Girardeau I-55

      3253 William Street, Cape Girardeau
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      Welcome to Holiday Inn Express & Suites Cape Girardeau I-55
      Welcome to Our Cape Girardeau Hotel. Just off I- 55 at exit 96, the Holiday Inn Express Hotel & Suites Cape Girardeau I-55 offers hotel guests 102 spacious, contemporary suites. Vacation and business guests alike choose these accommodations for a comfortable and convenient stay. Our Cape Girardeau, Missouri hotel is just minutes from Southeast Missouri State University, where guests are encouraged to cheer on the Redhawks in football and basketball. We're also only 10 miles from Trail of Tears State Park, so families can enjoy picnics, hiking, biking and fishing. Be sure to stop by our Old Downtown area where you will not only enjoy a variety of shops and restaurants, but you can enjoy the great view of the Mississippi River. Business travelers appreciate our Cape Girardeau, Missouri hotel's convenient location close to St. Francis Hospital, Southeast Missouri Hospital, Doctors Park, the Show Me Center, Procter & Gamble, Mondi, Shawnee Park and Biokyowa. We provide two spacious meeting rooms, as well, which feature A/V equipment ideal for business functions or special events. With the help of our professional staff, your event can be a success. At our Girardeau hotel, we know it's the extra perks that make your stay unforgettable. We provide an indoor pool and well-equipped fitness center to help you relax and unwind. Be sure to stop by our breakfast bar each morning, too, for biscuits, eggs, fruit and our signature cinnamon rolls. We look forward to your next visit!
      Features Each of our Cape Girardeau, Missouri hotel's guest rooms are suites, which means that you'll enjoy a microwave, refrigerator, 37' flat screen Tvs, wet bar, n, cable TV and even a Nintendo system in every room.

      Business Services

      Courier Service
      Wireless Data Connection
      Business Center

      Health and Fitness Center (On-site)

      Health/Fitness Center On-Site

      Entertainment and Recreation

      Indoor Pool

      Housekeeping and Laundry Services

      Daily Housekeeping

      Weekly Housekeeping

      Dry Cleaning Pickup or Laundry Valet

      Same Day Dry Cleaning


      Safety Deposit Box available at Front Desk

      Porter Bellman


      Number of restaurants: 1

      Hotel Restaurants

      Popeye's Chicken
      Location:  On same complex as hotel
      Serves:  Lunch, Dinner

      Nearby Restaurants

      Red Lobster
      Location:  On same complex with hotel
      Serves:  Lunch, Dinner
      For those persons savory seafood, this is the place. Just a few yards from the entrance to the hotel convenient and easy to walk to. Restaurant is a newly renovated restaurant as well and offers a wide selection of seafood.
      Cracker Barrel
      Location:  Located on the same complex as the hotel
      Serves:  Breakfast, Lunch, Dinner
      Enjoy the well renowned service and food that so many people like. Located on the same complex as the hotel just a short walk around the corner. Specializes with breakfast but offers home cooked style meals for lunch and dinner.
      Texas Roadhouse
      Location:  Located on the same complex as the hotel
      Serves:  Lunch, Dinner
      Get a little taste of Texas with their signature hand cut steaks fall off the bone ribs ice cold beer and much more. Located within a short walk of the hotel on the same complex.
      Olive Garden
      Location:  Located right in front of the hotel
      Serves:  Lunch, Dinner
      Enjoy a taste of Italian at this restaurant. Located just a hop skip and jump from the front of the hotel entrance.
      Panera Bread
      Location:  Located on the same complex as the hotel
      Serves:  Breakfast, Lunch, Dinner
      Featuring fresh baked breads delicious sandwiches soups and pastries. Located on the North East corner of the complex from the hotel.i
      Honey Baked Ham Cafe
      Location:  Located right next door to hotel
      Serves:  Lunch, Dinner
      This Cafe is packed full with a variety of deli sandwiches featuring the famous honey baked ham.
      Outback Steakhouse
      Location:  Just West of the hotel
      Serves:  Lunch, Dinner
      Inspired by the adventurous spirit of Australia Outback Steakhouse has been and innovator in the restaurant industry by creating bold iconic flavors served in a quality casual environment. Steaks seafood burgers ribs etc
      Beef O'brady's
      Location:  1 mile from the hotel
      Serves:  Lunch, Dinner
      Sports bar and restaurant
      Serves:  Breakfast, Lunch, Dinner
      Open 24 hours. Serves breakfast, lunch and dinner. Best variety of pancakes around.

      Guestroom data services

      Wireless Data Connection

      High-speed Internet Access

      Business Center data services

      Wireless Data Connection

      High-speed Internet Access

      Public space data services

      Wireless Data Connection

      High-speed Internet Access

      • We have free parking for all of our guests in the hotel. Conveniently located on all sides of the hotel.
      • No pets allowed, please contact the hotel direct for available options. There are several comfy boarding options that we will be happy to assist you with. Service animals may not be left unattended at any time in the hotel.
      • American Express
      • Carte Blanche
      • Diners Club
      • Discover
      • JCB
      • MasterCard
      • Visa
      • English


      • Number of rooms: 8
      • Parking
      • Service Animals Allowed

      Hotel areas that are accessible:

      Guest Rooms

      Exercise Facility


      Concierge Desk

      Business Center

      Registration Desk

      Public Entrance

      Hotel areas with accessible routes from accessible public entrance:

      Exercise Facility

      Meeting Room/Ballroom Area


      Business Center

      Registration Desk


      Accessible Guest Rooms

      Hotel provides the following:

      Portable Tub Seats

      TTY for Guest Use

      Closed Caption Televisions

      Accessible Self Parking

      Van Accessible Self Parking

      Number of Accessible Meeting Rooms: 2